Fatty acid synthesis requires energy in the form of ATP (adenosine triphosphate) and NADPH (nicotinamide adenine dinucleotide phosphate). The exact number of ATP molecules required can vary depending on the specific pathway and organism, but here's a general breakdown:

1. *Activation of acetyl-CoA*: 2 ATP molecules are required to activate acetyl-CoA, the starting material for fatty acid synthesis.
2. *Malonyl-CoA formation*: 1 ATP molecule is required to form malonyl-CoA from acetyl-CoA.
3. *Fatty acid chain elongation*: Each round of fatty acid chain elongation requires 1 ATP molecule.

Assuming a typical fatty acid synthesis pathway, which involves the formation of a 16-carbon fatty acid (palmitate), the total ATP requirement would be:

2 (acetyl-CoA activation) + 1 (malonyl-CoA formation) + 7 (chain elongation) = 10 ATP molecules

Keep in mind that this is a simplified calculation and actual ATP requirements might vary depending on the specific organism, tissue, or conditions.

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